Russia's communications regulator said the ban was a response to restrictions placed on its media there.
It said there had been 26 cases of "discrimination" against Russian media by Facebook since October 2020.
There were also reports that the use of Twitter had been restricted by the Russian regulator, Roskomnadzor, on Friday evening.
Facebook's president of global affairs, Nick Clegg, said that "soon millions of ordinary Russians will find themselves cut off from reliable information".
Facebook had previously been limited in the country, along with platforms including Twitter.
Although its use was restricted, Facebook had not been blocked entirely in the country.
On Friday Russian media quoted the regulator as saying that Twitter had been restricted following a request by the prosecutor general from 24 February, the day of the invasion of Ukraine.
Twitter did not immediately respond to the BBC's request for comment on the reports.
Meta, the company that owns Facebook, said last week though that it had restricted Russian-backed outlets across the European Union and was globally demoting content from state-affiliated media.
It had also refused to stop fact-checking several Russian state media outlets, including RT and Sputnik.
Russia's media regulator said in a statement: "Since October 2020, 26 cases of discrimination against Russian media and information resources by Facebook have been recorded."
The statement says the block on Facebook platforms has been introduced "to prevent violations of the key principles of the free flow of information".
In response Meta said: "We will continue to do everything we can to restore our services so they remain available to people to safely and securely express themselves and organize for action."
The White House said it was "deeply concerned" by Russia's decision to block the US company, and said the move was part of a broader effort to "choke off information".
"This is part of their effort ... to cut off a range of information from their public," White House spokesperson Jen Psaki said, adding that the US was also "concerned about the threat on freedom of speech in the country".
The ban comes after Russia's Parliament passed a new law this week imposing a jail term of up to 15 years for spreading intentionally "fake" news about the military.
The BBC also said it would temporarily suspend the work of all its journalists and support staff in Russia following the introduction of the law.
Other technology and social media giants have faced pressure to respond to the crisis in Ukraine from investors and their users.
Apple, for example, has halted all product sales in Russia, and limited other services such as Apple Pay and Apple Maps. Its retail stores in the country have closed as well.